Erythrocytes functioning and implications in respiratory diseases

It was a conundrum as to how erythrocytes could survive for up to four months without mitochondria (to power their needs, as glycolytic machinery was inadequate to generate the ATP needed) and nucleus (as there was no intelligent coordination of membrane protein function).  While the murburn model of electrophysiology averts the latter issue, the energy needs are compensated by the newfound role of tetrameric hemoglobin, which serves as a murzyme ATP synthase. The interactive scheme for binding other milieu components like bisphosphoglycerate and NADH were also explained. Further, the new insights also explain that murburn post translational modifications (phosphorylations, glycations, etc.) can have tremendous implications in our understanding of normal and patho physiological statures.